ABSTRACT
To study the incidence, types, geographical distribution, and risk factors of congenital anomalies [CAs] in a teaching hospital. A total of 5864 neonates were examined for CAs between October 2010 and October 2011 in Al-Ramadi Maternity and Children's Teaching Hospital, Al-Ramadi, Western Iraq. Data include: neonate's name, gender, weight, and type of CAs, mother's age, residence, education, parity, consanguinity, smoking, illness, drugs, and ultrasound [U/S] results, father's age and smoking, and family recurrence of CAs. For every case, 2 controls were selected. Types and incidence of CAs was calculated. Odds ratio and confidence interval was utilized for risk factors evaluation. Overall CA incidences were 40.5/1000 for total births, 40.8/1000 live births, and 270.0/1000 for stillbirths. Twenty percent of CAs was found as multiple, 80% single, 63.8% major, and 36.2% minor. The cardiovascular system was found most affected, followed by genito-urinary system. Low birth weight, male gender, maternal smoking, consanguinity, parity, and CAs family recurrence were found to be significant risk factors, and oligohydramnios, polyhydramnios, and positive CAs by U/S, found as significant co-factors associated with CAs, while parental age, and maternal education were not considered risk factors. Although the incidence of CAs was lower than the Al-Fallujah rate, it is still higher than many developed and developing countries. Amniotic fluid volume changes in U/S may hide an ominous CA, and maternal smoking exposure during pregnancy and consanguinity may expose the family to a congenitally anomalous delivery
ABSTRACT
Scabies is relatively a highly contagious inflammatory skin disease caused by infestation with a parasite Saivoptes s_cabici. The pathogenesis of scabies is mainly due to and starts after sensifl/ation of the host to the mite and its products which provokes an allergic response, responsible for a wide spectrum of clinical and histological manifestations. To determine whether specific IgE against scabies can show a cross reactivity with house dust mites allergens. The level of specific IgE. Against Sarcoptes scabiej_ var hominis, Dermatophagoides faiinae and Dermatophagoides pteronyssinus was measured in 30 scabietic patients by ELIZA method and [he results was compared using t test with that from the control group. There was a high statistical correlation [P<0.001] between the data of specific IgE against Sarcoptes scabiei var hominis, Dermatophagoides farinae and Dermatophagoides pteronyssinus in the patient group in comparison with that from the control group. Some antigens from Sarcoptes scabiei body and its fecal pellets cross react with house dust mites body and feces, since they are related phylogenetically. So specific IgE against scabies can cross react with house dust mites, Dermatophagoides farinae and Dermatophagoides pteronyssinus, which are important allergens responsible for extrinsic asthma. This cross reactivity may explain the association of severe form of scabies infestation with atopic diseases and the persistence of symptoms in some cases even after proper treatment of the disease